Magnetically modified biopolymers can be used either as in situ reporters of local enzymatic activity or as scaffolds for cell growth with adjustable mechanical properties.

Soft tissues development, degradation, healing, remodeling and regeneration are all processes driven by tissue-specific enzymes. Quantification of enzymatic activity in situ is a key factor to monitor those processes and predict the biological response of tissues to a treatment. Existing diagnostic techniques are invasive and can only estimate in situ enzymatic activity indirectly.

Our exclusive technology can noninvasively detect the enzymatic activity in situ. It is based on binding magnetic nano-particles (NP) to macromolecular enzyme substrates significantly larger than individual NP to form Magnetically Functionalized Substrates (MFS).

These NP are specially designed to change their configuraartion after MFS gets digested in response to enzymatic activity producing changes in Magnetic Resonance Imaging (MRI) signature. MFS can be combined with existing regenerative scaffolds, and remodeling processes can be monitored with MRI. We are currently working on MFS to report the activity of specific matrix metalloproteases (MMP) using collagen as substrate.

We also offer modified and non-modified biomaterials and services for tissue engineering. Contact us for inquires.